scientific knowledge doubles about every 3 years. In
10 years we will know 10 times more about how and we age, and
to treat it. Advances in the science of aging (gene therapy and other
fields) and in anti-aging supplements will almost certainly lead to
better ways to prevent or reverse the most direct cause of aging,
telomere dysfuction. If you are over 60 it makes sense to
up with new developments to try to extend your life long enough to
reap these future benefits. Reading popular Anti-aging Books can help.
There is also a practical "social" reason to try to preserve
your youthfulness. Demographic
studies estimate that by 2050 the population of people over the age of
80 will triple. If advances
in anti-aging research occur too slowly or are not made readily
available to everybody, this aging
population will become a tremendous burden on society. It makes good
political sense to keep
the elderly as healthy, productive and self sufficient as
possible. Anti-aging research may be the only real option that can
address this developing social problem.
wait for anti-aging news updates?
There are a number of organizations and websites dedicated to
anti-aging research and news.
Foundation publishes a news web page on their
popular websites that occasionally have anti-aging news.
Anti-aging News Log
news stories appear every year. I only list a few of the more important ones.
July 2011 - Rapamycin, an immunosuppressant used to prevent transplant organ rejection, was used to treat progeria and was able to slow down certain aspects of normal aging. Read the abstarct at: AGING Journal
Jan 2012 - Stem cells
may be the basis for a new anti-aging treatment. Progeria in
genetically engineered mice was completely reversed through the
injection of stem cells. National Geographic
June 2013 - UC Irvine researchers have shown an extract from the herb Rhodiola rosia (aka
golden root) increases the life of friut flies by 25%. Its anti-aging
action may benefit humans but this is not yet proven. The herb has been
used for centuries to reduce stress, fight fatigue and boost memory. Ref1 Ref2
July 2013 - Rapamycin has limited anti-aging effects. It was able to extend the lives of mice by 14%. Sci News
Aug 2013 - Metaformin a drug long used to control type 2 diabetes, has improved health and lifespan in middle-aged male mice by 5.83%. Medical News Today MNT
Dec 2013 - NAD (nicotinamide adenine dinucleotide) - a metabolic coenzyme can lead to a reversal of some symptoms of aging in mice. Ref1
Aug 2012 - We
are following news on: various
extracts of Astragalus
Sep 2012 - Telomerase activators
are an active area in anti-aging research. Sierra Sciences is
thousands of substances and biological extracts every month for
telomerase activation activity.
Hundreds of compounds and dozens of
extracts have been shown to have telomerase activation
of these (TA-65,
Product B) are being marketed.
Supplements with these activators are
supposed to help preserve or even
extend telomere length and thus extend longevity. Little independent
published clinical research exists to support this and the company's
marketing pitches seem to be a little
shady. That said, the product claims
might be true. These supplements may have other health
possible I would recommend
to wait until this product receives positive reviews and
from the scientific community. Read the Product
B critical article "here we go again" (11/25/2014).
My main criticism of most of currently
(2013) available telomerase activator supplements is that they
are too expensive for
routine use. Some experts question their effectiveness and law
suits have been
brought against TA-65.
If you really want to try it click on the images below. The
supposedly have the same active ingredient as TA-65,
are more reasonably priced.
Sep 2014 - Science Daily reports that scientists have identified a gene that slows down aging.
Jan 2015 - Stanford
- using modifed RNA, scientists lengthen telomeres in
cells by as much as 1,000 nucleotides turning back the
clock in these cells by the equivalent of many years of human life.
March 2015 - The Mayo
Clinic and Scripts Research Institute discover a new class of
age reversing drugs (senolytics) that may become available
over the counter.
The drugs mimic the effects of calorie restricted diets.
Oct 2015 - Science Blog
has a report about a conference about the comparative biology
The same author has a good blog covering telomerase
Sep 2015 - BioViva first reports Gene theraphy successfully and safely lengthened human telomeres.
Dec 2015 - LifeExtension
reports that the FDA has approved an anti-aging study on
metformin, a drug widely used in the treatment of type II diabetes. A
related headline: "New AntiAging Drug Could Extend Human Life Spab to
120 Years" (Ref).
The good news is that this common drug is relatively inexpensive ($4
for a month's supply). The bad news is that metformin can have side
effects such as causing a drop in vitamin B1, B12 and Magnesium levels.
The study is expected to take 5 to 7 years to complete (Ref).
Apr 2016 - Eureka Alert
reports that nicotinamide riboside (chemically similar to
B3) can, in mice, restore regeneration processes that normally
deteriorate with age by "revitalizing" muscle stem cells in elderly
Similar restoration occured in brain and skin stem cells. The
treatment restores declining mitochondrial functioning. Treated
mice "live longer than the mice that didn't get it". These results may
be a breakthrough in regenerative medicine and a possible new treatment
for muscular dystrophy (myopathy). This advance is not a "cure" for
aging but is a step in the right direction.
Aug 2016 - MDI Biological Lab
report that they now know what the common genetic regulators are that
govern limb regeneration across various species. The investigators
believe the regeneration mechanisms are not species specific but have
been conserved by evolution across many species about 420 million
years ago. The identification of a common cross species genetic
signature for limb regeneration suggests that treatment for faster
wound healing and limb regeneration are now the subjects of
practical research. The timeline before real treatments become
available is now directly tied to the availablilty of research funding.
This research is related to anti-aging research because it advances our
understanding of how gene expression works.
Aug 2016 - Bioviva Inc. tests
confirm that, using gene injection therapy, they have successfully
increased telomere lengths from 6.71kb to 7.33 kb. This
measurement translates to an approximately a 20 year regression in the
biological age of the white blood cells under test. In
September 2015, 44 years Elizabeth Parrish, CEO of Bioviva
was the first human being to receive experimental anti-aging gene
theraphies designed to work against muscle mass loss and stem cell
depletion. This may be the beginning of the anti-aging
breakthroughs we are all waiting for.
Dec 2016 - Salk Institute scientists, using cellular reprogramming, have increased the average lifespan of mice with progeria by 30 percent and also rejuvenated some of their tissues. Reported in a 2016 study,
this kind cellular reprogramming is important, not because it
was progeria specific, but because it is promising demonstration
of epigenomic reprogramming. Adult mouse cells, from mice
with progeria, were reprogrammed to become undifferentiated, non
specialized pluripotent stem cells. The expression of four epigenetic
marks (Yamanaka factors) in these cells was modified to allow the cells to develop with fewer defects.
The success of this more general approach (understanding and
controlling epigenetic "marks") to anti-aging is a real
breakthrough in the science of anti-aging. That said, years
of additional research is needed before techniques to control epigenetic factors become safe enough be tested in clinical trials.
Aug 2018 - Bioviva Inc. updated their report to confirm that the gene injection therapy first done on
Elizabeth Parrish has been very successful. Elizabeth Parrish is now (2019)
47 years old. Quoting from the article; "... we think that Liz's
biological age is closer to a 30 year old or younger.". She has made
several youtube videos about this and subjectively does appear to be younger. One youtube almost hour long video
and contains lots of understandable information about the genes associated
with aging, the role telomeres play in the aging process, and the
success of various other anti-aging theraphies. It should be noted that
there are many who think these therapies are unproven and
have acused Parrish of implementing an elaborate money making scam. So
far the treatments are far far too expensive for the average person. More confirming reports are needed to before we can fully accepting these very encouraging results.
Aug 2018 - Science Daily reports a promising safer way to use
gene therapy to reactivate the telomerase gene. Telomerase enzyme
reactivation is used to treat diseases associated with telomere
shortening such as cardiovascular, neurodegenerative and some aspects
of aging itself. Researchers from the Spanish National Cancer Research Centre have shown that the use of gene therapy vectors, such as adeno-associated viruses (AAV), that
do not integrate into the genome of treated cells, do not cause cancer
or increase the potential risk of promoting cancer through the
activation of telomerase. It may even reduce such risks. Some In this therapy, that can be administrated
with a single local injection, the gene activating factor is quickly
diluted and limits the telomere-reparative actions to only a few cell
divisions. So far this therapy has been successfully used in mice to
regenerate heart tissue and for diseases like aplastic anemia, and
idiopathic pulmonary fibrosis.
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