Antioxidant Supplement Dosage
Antioxidant Supplement Dosage
Programmed Death Theory of Aging Cellular Death Theory of Aging Aging Senescence Theories of Aging CDTA supporters of stimulating the natural production of antioxidants
claim that natural antioxidants provide better protection against
the damaging effects of free radicals than do antioxidant supplements.
One concern this group has is that the triggering mechanisms for the
production of natural antioxidants can be desensitized by the over use
of antioxidant supplements. The belief here is that a continuous
production of natural antioxidants brought on by very mild activation
of the Nrf2 protein is the healthiest possible state for human body.
Anything that disrupts this does more harm than good. They also claim
that the natural antioxidant production may be disrupted by taking too
much of known Nrf2 activators such as curcumin or resveratrol. Some
supporters in this group believe that current antioxidant
over-supplementation has already created serious health issues.
main proponents of CDTA support the idea of taking significant amounts
of readily available external antioxidants such as vitamin C, E, and
other supplements. Many of them recommend taking one or more grams of
Vitamin C daily. They believe this can safely reduce the amount of
cellular damage free radicals generate. The good news is that some
research actually does support this claim. The not so good news is that
the concerns of the pro natural antioxidant camp are not being taken
seriously. It is also true that, by focusing on a few well known
antioxidants, too little attention is being paid to the role
antioxidants play in the body.
Humans utilize numerous
(1000s) types of antioxidants and their variants. Each antioxidant's
biochemical reactions with different kinds of free radicals are unique.
A few antioxidants, such as Vitamin A, C, and E are popular and are
well known. Most others such as Uric acid, best known for its
association with gout, are much less well known but are equally
important. Using this antioxidant as an example, Uric acid, which in
humans happens to have the largest blood concentration of all
antioxidants, is responsible for over half of the antioxidant capacity
of human blood serum. Uric acid can reduce oxidative stress caused by
high-altitude hypoxia. Another such antioxidant is Glutathione (GSH). It has been called "the mother of all antioxidants",
and considered by many to be the body's most essential
antioxidant. It is produced and found within all human cells and is essential for proper functioning of the immune system.
GSH levels in the blood fall with poor health and increasing
age. As a biomarker, GHS blood levels, have been associated with
longevity. Glutathione works synergistically with many antioxidants and
GSH levels in the body can be raised by Vitamin C and
Selenium. A great many antioxidants that counteract free
radicals also inhibit viruses and bacteria. Most of this CDTA related
antioxidant research is only reported in technical journals but the
research itself suggests that lots of interesting anti-aging tidbits
being put on the shelf for future study or are under reported.
human body has several enzyme systems that fight free radicals by using
antioxidants (vitamins A, C, E, and the mineral selenium) we can only
get through our diets and/or by supplements. Vitamins A, C, and E are
also essential nutrients. Dietary deficiencies of these antioxidants
can cause specific diseases and possibly lead to other chronic and/or
degenerative health problems. A Beta-carotene (vitamin A) deficiency
can cause night blindness. Vitamin C deficiency can cause scurvy.
Vitamin E deficiency can causes nerve conduction problems. In the U.S.
a diet rich enough in fruits and vegetables (6 to 8 daily servings) can
prevent such deficiencies and is highly recommended. In reality such an
ideal diet may be difficult to maintain. This presents a strong
argument for supporting the use of at least a few antioxidant
supplements but the possible negative long term effects of using large
amounts of such supplements are not yet well known. So far
general studies on this do report some negative effects but also
seem to be
inconclusive (Antioxidant Overuse) (Too Many Antioxidants).
Bickering amongst advocates of CDTA has left us with several pressing unanswered questions.
Should we rely on naturally produced antioxidants and limit our use of external antioxidant supplements?
What are the correct antioxidant supplement dosages you need to slow down the aging process?
are no agreed upon standards to go by. CDTA tells us cellular damage is
cumulative. This may mean the real answers are relative; i.e. they will
vary depending on how old you are. It is a well established fact that
the efficiency of many of the body's homeostatic mechanisms declines
with age. If you are getting older, say over 60 years of age, your
natural antioxidant defenses are slowly weakening. How long can you
rely on them to adequately protect you? The efficiency of the body's
digestive absorption of many foods, including the trace minerals that
the natural antioxidant systems require, slowly decreases with age. At
a certain point in life an increase in antioxidant supplements and/or
supplemental digestive enzymes may really be helpful. Several of the
antioxidants produced in our body are becoming available in the
The current interpretation of
CDTA's vague approach to anti-aging is that to slow down the rate at
which cellular damage accumulates you should increase your daily intake
of dietary antioxidants (fruits and vegetables) and perhaps take some
unspecified amount of various vitamins and anti-aging supplements. With
increasing age you may need to increase your intake of vitamins and
antioxidant supplements. Until the experts agree on supplement dosages
you will have to diligently research any supplement you are interested
There are hundreds of health supplements available on
market. Many scientific studies on the benefits of any given health
supplement are at odds with each other. Some claim taking supplements
has benefits while others claim there are few or no benefits, or that
supplements may even be harmful. The vitamin and anti-aging supplement
business has become a 23 billion dollar industry that is not very well
regulated. This has allowed the market to become full of overpriced
products that may have few real benefits. You need to be careful.
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