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- Many small advances in anti-aging, that can potentially extend the human lifespan, are constantly occurring. Here, as explained by the scientists behind them, are links to two such advances: young blood and genetic mutation.
premise of this website is that anti-aging research on various fronts
will bear fruit within the next 10 to 15 years and that everyone,
if they want to, will then be able to extend their lifespan
indefinitely. Many people, including well known inventor and scientist Ray Kurzweil (Ref)(biovideo),
this and are taking steps to ensure they see that day. I strongly agree with what Ray says in his video. If
you are already reasonably healthy, it is easy to make
the life changes needed to live an extra 10 to 15 years. The recipe to
do this is fairly simple. You need to do a moderate amount of exercise
3 to 5 times a week. You need to change your diet to include more
fruits and vegetables, and less sugar, less refined carbohydrates,
and less saturated fat. In addition to this you need to take a
multi-vitamin/mineral supplement and extra vitamin C and Omega 3 Fatty
Acids (fish oil) on a daily basis. If you are over 45,
occasionally taking a few anti-aging supplements (ex. DMAE,
Acetyl-l-Carnitine, l-carnosine) once or twice a week can be helpful.
you are over 60 and/or suffering from any specific aging related
symptoms you may want or need to take additional supplements. Taking
additional anti-aging supplements is helpful but it is easy to get
carried away and go overboard. This has to be determined on an
individual basis. Even if you are over 60, if you are more or less
healthy, the extra cost
of taking small amounts of too many supplements to do blanket
supplementation may outweigh any small additional benefits you may get.
This is especially true if you don't know what additional supplements
you really need and what the best dosage for each supplement is. If you
want take many supplements be sure to research all the possible
supplement interactions and work out some sort of schedule to minimize
I looked at Ray Kurzweil's great list of 77 supplements.
Personally I would skip the skin creams, the intravenous supplements,
and the aspirin and Lipitor. Vitamin C, Niacin, garlic and a few of the
other listed supplements, in the correct dosages, will help keep the
LDL and HDL Cholesterol blood levels within a healthy range. It is best
to keep things simple. If you are already healthy and are doing the
basics, taking too many additional supplements may is not a bad idea but probably is not necessary.
- Currently the general political mood seems to be very favorable for anti-aging research.
There are no international recognized political programs to stop
aging or extend life but since 2012 a few pro-immortality political
parties have sprung up. Their aim is to support anti-aging and life
extension research, and to help provide access to advances in these
areas to everyone. Among the numerous organizations supporting
anti-aging research, the SENS (Strategies for Engineered Negligible
Senescence) organization has come up with an anti-aging research plan.
They want to develop anti-aging therapies to repair most forms of
cellular damage. SENS is a charitable organization. Any anti-aging
advances resulting from funding it provides will become readily
available public knowledge. In addition to the normal scientific
research there is the $1,000,00 Palo Alto Longevity Prize that is being
offered to anyone who can come up with an effective anti-aging
As of 2015, all known anti-aging treatments are
only partially effective. Depending on when one starts a comprehensive
anti-aging program, one can probably extend one's life by 10 to 25
years. Researchers from the Harvard School of Public Health estimated
that an anti-aging lifestyle can add 24.6 more productive years to
one's lifespan. Anti-aging knowledge increases at a rate of about 10
times every 10 years. This means that for most of us there should be
more than enough time to reap the anticipated benefits in anti-aging
- Genetic engineering is the key to understanding and defeating the aging process
because it can directly address the root causes of aging. Advances in
this field are producing more and more practical results and all the
tools needed to modify the human genome in any way we want are now in
hand. Advances in this area (CRISPR)
allow DNA base pairs to be inserted or deleted at any specific place in
our DNA. This means the human genome can now be precisely edited as
needed. The lifespan of old mice has been modestly increased using
telomerase gene therapy.
In humans, gene modification therapy has frequently been used for various medical problems. On September 15, 2015, Elizabeth Parrish
was the first human to undergo anti-aging gene therapy. Since the human
genome is not fully understood, ethical questions concerning its
modification have been raised (Ref).
It takes no genius to predict that anti-aging treatments will now
rapidly advance as our knowledge of the specifics of the human genome
2015 - The
issue of what the correct antioxidant supplement dosages should be
requires a little more research. Anti-aging theorists disagree on
this issue. We know that "excessive" level of antioxidants can be
more harmful than helpful. Ideally anti-aging treatment should to be
fine tuned on an individual basis. The key here would be to
measure and minimize the cumulative effects of different kinds of
stress on an individual basis. Easily measurable practical bio-markers
for effects of various types of stress on the body do not yet exist or
are not being used. When they are used it will be easy, through trail
and error, to customize individual antioxidant supplement dosages so
that everyone can have "optimum" levels throughout their life.
"Optimum" levels would maintain a safe reserve of protective
antioxidants in the body.
2013 - I consider some of Sierra Sciences advertising practices for TA-65
to be unethical and deceptive. The big issue I have is one of
scientific honesty. The company genetically engineered mice that
allowed telomerase to be switched off and on at an early age. TA 65 was
able to switch telomerase back on in these mice and allowed them to
live normal lives (Ref 1).
Using this to show how effective TA65 treatment is, is dishonest. This
is not how telomerase normally works and there was no real extension of
the lifespan beyond what it would have been without the genetic
modification. In normal mice the effects of TA65 were temporary and
little or no life extension was seen (Ref 2).
said, the product claims
might eventually be proven to be true. These supplements may also have
benefits. The advertising strategy may be a calculated guess that their
product will really work. If it does the dishonest advertising will be
forgotten. In the meantime I still recommend waiting until this product receives more positive reviews and
endorsements before spending a lot of money on TA-65. Read the Product
B critical article "here we go again" (11/25/2014).